NNC55-0396 Reduces SH-SY5Y Cell Damage Induced by Bupivacaine Hydrochloride
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چکیده
منابع مشابه
Neurotoxicity Induced by Bupivacaine via T-Type Calcium Channels in SH-SY5Y Cells
There is concern regarding neurotoxicity induced by the use of local anesthetics. A previous study showed that an overload of intracellular calcium is involved in the neurotoxic effect of some anesthetics. T-type calcium channels, which lower the threshold of action potentials, can regulate the influx of calcium ions. We hypothesized that T-type calcium channels are involved in bupivacaine-indu...
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Hyperglycemia can inhibit expression of the 8-oxoG-DNA glycosylase (OGG1) which is one of the key repair enzymes for DNA oxidative damage. The effect of hyperglycemia on OGG1 expression in response to local anesthetics-induced DNA damage is unknown. This study was designed to determine whether high glucose inhibits OGG1 expression and aggravates bupivacaine-induced DNA damage via reactive oxyge...
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We investigated the pharmacological properties and interaction domains of N-(3-aminobenzyl)-6-{4-[(3-fluorobenzyl)oxy]phenoxy} nicotinamide (YM-244769), a novel potent Na /Ca exchange (NCX) inhibitor, using various NCX-transfectants and neuronal and renal cell lines. YM-244769 preferentially inhibited intracellular Na -dependent Ca uptake via NCX3 (IC50 18 nM); the inhibition was 3.8to 5.3-fold...
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Bupivacaine is one of the most toxic local anesthetics. An increasing number of studies have shown that bupivacaine could induce intracellular oxidative stress and cause cell death. However, the mechanisms underlying its neurotoxicity are still unclear. In this study, we evaluate the neurotoxicity effect and the underlying mechanisms of bupivacaine in SH-SY5Y cells. First, we monitored the intr...
متن کاملNeuroprotective Effect of Ginkgolide B on Bupivacaine-Induced Apoptosis in SH-SY5Y Cells
Local anesthetics are used routinely and effectively. However, many are also known to activate neurotoxic pathways. We tested the neuroprotective efficacy of ginkgolide B (GB), an active component of Ginkgo biloba, against ROS-mediated neurotoxicity caused by the local anesthetic bupivacaine. SH-SY5Y cells were treated with different concentrations of bupivacaine alone or following preincubatio...
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ژورنال
عنوان ژورنال: Journal of Experimental and Clinical Toxicology
سال: 2020
ISSN: 2641-7669
DOI: 10.14302/issn.2641-7669.ject-20-3529